The Ovine Cathelicidin SMAP29 Kills Ovine Respiratory Pathogens In Vitro and in an Ovine Model of Pulmonary Infection

The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection.

Cathelicidins are antimicrobial peptides from sheep (SMAP29 and SMAP34), rabbits (CAP11 and CAP18), rodents (CRAMP), and humans (FALL39, LL37, and h/CAP18). In a broth microdilution assay against nine ovine pathogens, SMAP29, SMAP34, mouse CRAMP, CAP18, CAP18(31), CAP18(28), CAP18(22), and CAP18(21a) were the most active, with MICs as low as 0.6 microg/ml. Other cathelicidins were less active. ...

Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells.

SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membran...

Chemotherapy in Ovine Malignant Theileriosis

P53 Mutation in Ovine Pulmonary Adenomatosis

P53 is a protein which is related to DNA, and has been called tumor suppressor, and is coded in human by the gene TP53(1). This protein plays a vital role in complex organisms, and regulates cell cycle. It functions as tumor suppressor to prevent occurrence of cancer. P53 is called genome protector or arrowhead of genome protection or head of genome watchers, all of which indicate its protectiv...

Ovine Herpesvirus 2 Infection in Foal, Brazil

To the Editor: Malignant catarrhal fever (MCF) is an acute, generalized, and usually fatal disease previously thought to be restricted to mammals of the order Artiodactyla, often members of the subfamilies Bovinae, Cervidae, and Suidae (1). Although animals of the order Perissodactyla, family Equidae, have previously been considered not susceptible to ovine herpesvirus 2 (OvHV-2), we show that ...